Charleston Area Meeting

Monday March 12 

New Catalysts for an Old Reaction: Adding Flavor to the Kemp Elimination


Marcello Forconi 

5:00 p.m. Presentation

6:00 Reception 

College of Charleston, SSMB 129 (202 Calhoun Street) 

The Kemp elimination is a well-studied reaction in which the labile N-O bond of 1,2-benzisoxazoles is cleaved, resulting in an irreversible ring-opening that produces 2-cyanophenols. The most common pathway for this reaction involves the base-catalyzed removal of the proton attached to the C3. However, new data strongly suggest that cytochrome P450 catalyzes the Kemp elimination via an alternative redox, Fe(II)-dependent, pathway. To determine the extent of catalysis provided by cytochrome P450, we used a simple system formed by metal ions coordinated to water-soluble porphyrins. Our results show that this simple system (as well as other heme-containing proteins) provides significant catalysis, and likely uses the same catalytic tools employed by cytochrome P450. Overall, our findings tie back to the bigger picture that many natural and artificial systems (including simple, unoptimized ones) catalyze the Kemp elimination with substantial rate accelerations. 

Dr. Forconi is an Associate Professor at the College of Charleston.  he received his B.S. and M.S. from the University of Bologna, Italy, and his Ph.D. from the University of Sheffield, United Kingdom.

Save the Date!

The annual SC-ACS Undergraduate Poster Session, Awards Meeting, and Dinner will be Thursday April 19 at Claflin University.

5:00 Set-up Posters

5:30 Social Hour and Poster Session

6:15 Dinner

7:00 Presentation of Awards

7:30 Presentation by Dr. Michael Myrick, S.C. Chemist of the Year 

Dr. Myrick's profile photo 


Congratulations to Dr. Angela Peters of Claflin University who received the E. Ann Nalley Regional Award for Volunteer Service at the 2017 SERMACS meeting in Charlotte on November 11 at the awards luncheon. This award recognizes ACS volunteers who have contributed significantly to the Society, particularly at the SE Region level.  She has served on the board of SERMACS, Inc. and most recently was the general chair of SERMACS 2016 in Columbia. Angela has served as the chair of the South Carolina Section and in 2012 received the E. Ray McAfee Distinguished Service to the Section Award from the South Carolina Section.  In addition to other honors in 2005 she was named the SC Governor's Professor of the Year.

SC-ACS @ Soda City





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